Three activists invade a laboratory with the intention of releasing some monkeys and chimps. What they do not know is that these animals are under experience, infected by the virus of rage. The activists are immediately killed and the animals escape. Twenty-eight days later, Jim wakes up from a comma alone in a abandoned hospital. He leaves the place and finds out that London is desert, apparently without a living soul. Then, he meets Selena and her friend Mark and he is informed that all the population died. People got infected by the monkeys, and the infected ones attacked the survivals. Jim decides to go home with the new friends and see what might have happened with his parents. Then, they are rescued by Frank and his daughter Hannah. They listen to a broadcast message from Manchester and they decide to go to the place guided by the broadcasting. Lots of action happens with the group while trying to escape from mutant zombies.