After a wild night out, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill, and as her condition worsens, becomes unable to distinguish fact from fiction. Meanwhile, Cuddy and Wilson attend a medical conference for pharmacology and public policy. House tags along, planning to use the outing as an opportunity to push a personal agenda, but things don’t go as expected.